We present the case of a 55-year-old woman diagnosed with an ST-elevation myocardial infarction, on the background of receiving chemotherapy for metastatic ovarian cancer. She underwent primary angioplasty followed by a repeat angioplasty two hours later due to acute stent thrombosis. She was subsequently diagnosed to have acute severe thrombocytosis. This case highlights the role of exploring a broad differential diagnosis in cases of recurrent acute stent thrombosis and presents a very rare case of reactive thrombocytosis in a patient on systemic anti-cancer treatment presenting as a myocardial infarction. It highlights the benefits of inter-specialty liaison for delivering better patient care, especially in complicated treatment regimes for a number of disorders in various medical specialties.