Combination Exercise Regimen and Resveratrol Intake Can Be Considered For Cardiac Rejuvenation Therapy in the Aging Process
Aging is an inevitable process of life. Become progressively disorganized and degraded with age occurring as a consequence of physiological aging. This process has many different exercise regime or supplementary resveratrol intake molecular biology mechanisms to regulate different aging grade. Indeed, their combination in the molecular biology interaction is our intriguing in this study. We purchased natural aging mice and gene type senescenceaccelerated SAMP8 mice to examine different molecular biology interaction of survival and apoptosis signaling after exercise training, supplementary resveratrol intake, and combination. Histological pathophysiology of age-related cardiac disease was examined using hematoxylin-eosin and Masson's trichrome staining. Apoptosis cells were determined using TUNEL staining. Results showed PGC-1α and SIRT-1 increased were observed in natural aging after exercise training and supplementary resveratrol intake (p<0.05). In the genetic type of genetic senescence-accelerated mice SAMP8, left ventricular weight observed decreased after exercise training, supplementary resveratrol intake, and their combination (p<0.05). However, TUNEL analysis results showed combination exercise training and supplementary resveratrol intake apoptosis cells has significant decreases (p<0.05). We suggest resveratrol intake can help exercise training therapy age-related cardiac disease.