Medical - Clinical Research & Reviews


Lack of Association between TRP Gene Polymorphisms and Complication of Medication Overuse Headache in Migraine Patients

Masaaki Ishibashi, Hideyo Kasai, Hirotaka Katoh, Masakazu Ishii.

Purpose: We studied the association between the polymorphisms of TRP channels, such as TRPV1 (vanilloid 1), TRPM2 (melastatin 2), TRPM8 (melastatin 8) and TRPA1 (ankyrin 1), and the complications of medication overuse headache (MOH) in patients with migraines.

Methods: Forty-seven migraine patients (6 males and 41 females; 36.4 ± 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 ± 9.9 years) who had migraines participated in this study. The genotypes for the TRPV1 (rs222747, rs222749 and rs8065080), TRPM2 (rs1556314), TRPM8 (rs10166942 and rs11562975) and TRPA1 (rs920829 and rs11988795) gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.

Results: No significant differences were observed in the genotype distributions of TRPV1, TRPM2, TRPM8 or TRPA1 between migraines and MOH.

Conclusion: TRP gene polymorphisms were not involved in the aggravation of migraines due to the overuse of medication.