Gynecology & Reproductive Medicine


The Role of Micronutrients in the Treatment of Idiopathic Abnormal Sperm Parameters

Elmahaishi LM, Abbas AA, Elmahaishi MS

In spite of the presence of large number of male infertility pharmaceuticals agents and strategies, there is a renewed interest in remedies from micronutrient sources because of their lesser side effects and low cost. In this clinical trial that included male subjects aged from 20 to 60 years with at least 1 year of infertility and abnormal semen analysis who received 3 -6 months’ treatment with a Cyclofert men that contains (l-carnitine l-tartarate 1g, N – Asetyl - cysteine 600 mg, 40 mg zinc, Lycopene 20 mg, 60 mg vitamin E, 200 mg vitamin C, 80 mg glutathione, 200 μg selenium, 100 mg coenzyme Q10 and 400 μg folic acid. Theses micronutrients were given in a form of two tablets/ twice a day for 6 months). Sperm parameters (count, motility, and morphology) and pregnancy incidence were monitored before and after treatment. The collected data showed that there was an overall progressive motility after 3 and 6 months of treatment. Moreover, the sperm count increased by 64% (3 months), (6 months) 88% (α = 0.00, 1, at P<0.05) compared to the untreated group. Furthermore, treatment for three and six months significantly improved the sperm morphology (p<0.05). These positive changes ameliorated the women’s ability to get pregnant in which 30 % of women got pregnant after 6 months of the treatment. However, all of these improvements are proportional with the duration of treatment.